Ipamorelin Growth Hormone–Releasing Peptide (GHRP)

Ipamorelin is a selective growth hormone–releasing peptide (GHRP) designed to stimulate the pituitary gland to release natural growth hormone (GH). Unlike earlier GHRPs, Ipamorelin is known for its high specificity, promoting GH release with minimal impact on cortisol or prolactin levels.

It is widely referenced in research and clinical settings focused on body composition, recovery, and metabolic support.

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Key Benefits & Characteristics

• Stimulates natural pulsatile growth hormone release

• Supports fat metabolism and lean body composition

• May assist with muscle recovery and repair

• Promotes restorative sleep quality

• Supports connective tissue, skin, and joint health

• Minimal stimulation of hunger compared to other GHRPs

• Low incidence of water retention when compared to exogenous GH

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Mechanism of Action

Ipamorelin works by binding to ghrelin receptors (GHS-R) in the pituitary, signaling the release of endogenous growth hormone without significantly affecting other hormonal pathways. This selective action makes it a preferred option in GH-focused protocols.

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Common Research Applications*

• Body composition optimization

• Recovery and tissue repair

• Age-related decline in growth hormone

• Sleep and recovery support protocols

• Often paired with GHRH analogs (e.g., CJC-1295) for synergistic GH release

Reference draw:

• 30 units (0.3 mL) per administration

• Commonly referenced as once daily, typically before breakfast

• Subcutaneous administration into the abdominal fatty layer